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A century at the chemistry-biology interface

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The field of chemical biology is now hitting its stride. Chemical biologists have developed essential tools that are being used to illuminate complex cellular events. The application of chemical principles to biological phenomena has revealed new opportunities for drug discovery. This report highlights recent progress and exciting new directions in chemical genetics and drug discovery.

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Figure 1: The Hsieh-Wilson lab has synthesized several different 'sulfo-forms' of chondroitin sulfate.
Figure 2: The beads-on-a-string diagram of polyketide synthases is obsolete.

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  1. the Department of Chemistry, Stanford University, Stanford, 94305-5080, California, USA

    Jennifer J Kohler

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  1. Jennifer J Kohler
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Kohler, J. A century at the chemistry-biology interface. Nat Chem Biol 2, 288–292 (2006). https://doi.org/10.1038/nchembio0606-288

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