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Ribonucleic general acid

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Ribozymes are enzymes comprised of RNA that fold into three-dimensional structures and that catalyze chemical reactions central to all cells. A new study shows that ribozymes, like proteins, may use general acid catalysis as part of their catalytic toolkit.

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Figure 1: General acid catalysis by the HDV ribozyme.

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Strobel, S. Ribonucleic general acid. Nat Chem Biol 1, 5–6 (2005). https://doi.org/10.1038/nchembio0605-5

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