Skip to main content
SpringerLink
Log in

Possible new RNA intermediate in RNA silencing

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

SGS3 is essential for antiviral silencing and the biogenesis of several classes of siRNAs in plants, but until now no biochemical function has been ascribed to it. Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A model for SGS3-mediated generation of siRNAs.

References

  1. Fukunaga, R. & Doudna, J.A. EMBO J. 28, 545–555 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Mourrain, P. et al. Cell 101, 533–542 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Voinnet, O. Curr. Opin. Plant Biol. 11, 464–470 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Curaba, J. & Chen, X. J. Biol. Chem. 283, 3059–3066 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Glick, E. et al. Proc. Natl. Acad. Sci. USA 105, 157–161 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Li, F. & Ding, S.W. Annu. Rev. Microbiol. 60, 503–531 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kumakura, N. et al. FEBS Lett. (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Plant Pathology and Microbiology, Samer Elkashef and Shou-Wei Ding are at the Center for Plant Cell Biology, and Graduate Program for Genetics, Genomics and Bioinformatics, University of California, Riverside, California, USA. shou-wei.ding@ucr.edu,

    Samer Elkashef & Shou-Wei Ding

Authors
  1. Samer Elkashef
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shou-Wei Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elkashef, S., Ding, SW. Possible new RNA intermediate in RNA silencing. Nat Chem Biol 5, 278–279 (2009). https://doi.org/10.1038/nchembio0509-278

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0509-278

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation