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Redox sensing and histidine oxidation: no longer PerR-fect strangers

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Oxidation of cysteine residues is a well-described means of sensing oxidative stress. Analysis of a bacterial transcriptional repressor protein indicates that metal-catalyzed oxidation of histidine residues can provide oxidative stress control in a cysteine-independent fashion.

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Figure 1: Peroxides regulate PerR repression of antioxidant gene expression.

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  1. Department of Physiology and Biophysics, University of Iowa, Iowa City, 52242, Iowa, USA

    W Scott Moye-Rowley

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  1. W Scott Moye-Rowley
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Moye-Rowley, W. Redox sensing and histidine oxidation: no longer PerR-fect strangers. Nat Chem Biol 2, 234–235 (2006). https://doi.org/10.1038/nchembio0506-234

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