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Hypoxia sensing goes gauche

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By converting prolyl to 4-hydroxyprolyl residues, prolyl hydroxylases induce a conformational bias into proteins. This conformational preference is a result of a stereoelectronic gauche effect and is crucial for protein-protein recognition in oxygen sensing.

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Figure 1: Role of gauche effect in oxygen sensing.

References

  1. Loenarz, C. et al. Angew. Chem. Int. Edn Engl. 48, 1784–1787 (2009).

    Article  CAS  Google Scholar 

  2. Hirota, K. & Semenza, G.L. Biochem. Biophys. Res. Commun. 338, 610–616 (2005).

    Article  CAS  Google Scholar 

  3. Schofield, C.J. & Ratcliffe, P.J. Biochem. Biophys. Res. Commun. 338, 617–626 (2005).

    Article  CAS  Google Scholar 

  4. Hodges, J.A. & Raines, R.T. J. Am. Chem. Soc. 127, 15923–15932 (2005).

    Article  CAS  Google Scholar 

  5. Gorres, K.L., Edupuganti, R., Krow, G.R. & Raines, R.T. Biochemistry 47, 9447–9455 (2008).

    Article  CAS  Google Scholar 

  6. Jenkins, C.L. & Raines, R.T. Nat. Prod. Rep. 19, 49–59 (2002).

    Article  CAS  Google Scholar 

  7. Hon, W.C. et al. Nature 417, 975–978 (2002).

    Article  CAS  Google Scholar 

  8. Min, J.H. et al. Science 296, 1886–1889 (2002).

    Article  CAS  Google Scholar 

  9. Qi, H.H. et al. Nature 455, 421–424 (2008).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Danica Galonić Fujimori is in the Departments of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, California, USA. fujimori@cmp.ucsf.edu,

    Danica Galonić Fujimori

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  1. Danica Galonić Fujimori
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Fujimori, D. Hypoxia sensing goes gauche. Nat Chem Biol 5, 202–203 (2009). https://doi.org/10.1038/nchembio0409-202

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