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Back to the future of nucleic acid self-amplification

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The development of an autocatalytic, exponential replicator that is based solely on nucleic acids has implications for our understanding of the origins of life and potential applications in nucleic acid engineering.

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Figure 1: Autocatalytic ligase cycles.

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Authors and Affiliations

  1. Andrew D. Ellington is in the Department of Chemistry and Biochemistry and the Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA. andy.ellington@mail.utexas.edu,

    Andrew D Ellington

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  1. Andrew D Ellington
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Ellington, A. Back to the future of nucleic acid self-amplification. Nat Chem Biol 5, 200–201 (2009). https://doi.org/10.1038/nchembio0409-200

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