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Getting a handle on protein prenylation

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Protein prenylation plays a key role in the localization and function of many proteins, but the number and identities of prenylated proteins are unknown. A new study uses a multidisciplinary approach to provide a broad yet detailed snapshot of prenylation within the mammalian proteome.

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Figure 1: Detecting prenylation of the mammalian proteome using a modified prenyl donor.

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Authors and Affiliations

  1. James L. Hougland and Carol A. Fierke are in the Departments of Chemistry and Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA. fierke@umich.edu,

    James L Hougland & Carol A Fierke

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  1. James L Hougland
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  2. Carol A Fierke
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Hougland, J., Fierke, C. Getting a handle on protein prenylation. Nat Chem Biol 5, 197–198 (2009). https://doi.org/10.1038/nchembio0409-197

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  • DOI: https://doi.org/10.1038/nchembio0409-197

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