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The rule of four

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Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5′ untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.

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Figure 1: A G-quadruplex structure formed within the 5′ UTR of the NRAS mRNA is proposed to act as a translational repressor element.

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Authors and Affiliations

  1. Bruce A. Armitage is in the Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213-3890, USA. army@andrew.cmu.edu,

    Bruce A Armitage

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  1. Bruce A Armitage
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The author declares no competing financial interests.

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Armitage, B. The rule of four. Nat Chem Biol 3, 203–204 (2007). https://doi.org/10.1038/nchembio0407-203

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