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Self-reporting peptides illuminate the MHC groove

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Synthetic oligopeptides chemically modified with environmentally sensitive fluorophores enable real-time visualization of peptide binding to MHC molecules. This technology will expand our understanding of antigen presentation and enable visualization of fluorescent peptide binding to a wide variety of receptors in living cells.

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Figure 1: Location, location, location: self-reporting peptides identify peptide-receptive MHC molecules.

Katie Ris

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Authors and Affiliations

  1. Jonathan W. Yewdell and Avital Lev are in the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Building 33, 33 North Drive, US National Institutes of Health, Bethesda, Maryland 20892, USA. jyewdell@nih.gov,

    Jonathan W Yewdell & Avital Lev

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  1. Jonathan W Yewdell
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  2. Avital Lev
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The authors declare no competing financial interests.

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Yewdell, J., Lev, A. Self-reporting peptides illuminate the MHC groove. Nat Chem Biol 3, 201–202 (2007). https://doi.org/10.1038/nchembio0407-201

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