GPR30, a G-protein coupled receptor, is a recent addition to the family of receptors that bind to estrogens and antiestrogens. A new, selective compound for GPR30 has been developed to dissect the role of GPR30 in estrogen signaling.
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References
Bologa, C.G. et al. Nature Chem. Biol. 2, 207–212 (2006).
Jordan, V.C. J. Med. Chem. 46, 1081–1111 (2003).
Koehler, K.F., Helguero, L.A., Haldosen, L.A., Warner, M. & Gustafsson, J.Å. Endocr. Rev. 26, 465–478 (2005).
Chadwick, C.C. et al. Proc. Natl. Acad. Sci. USA 102, 2543–2548 (2005).
Losel, R.M. et al. Physiol. Rev. 83, 965–1016 (2003).
Filardo, E.J., Quinn, J.A., Bland, K.I. & Frackelton, A.R. Mol. Endocrinol. 14, 1649–1660 (2000).
Revankar, C.M., Cimino, D.F., Sklar, L.A., Arterburn, JB. & Prossnitz, E.R. Science 307, 1625–1630 (2005).
Pietras, R.J., Levin, E.R. & Szego, C.M. Science 310, 51–53 (2005).
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Weatherman, R. Untangling the estrogen receptor web. Nat Chem Biol 2, 175–176 (2006). https://doi.org/10.1038/nchembio0406-175
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DOI: https://doi.org/10.1038/nchembio0406-175
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