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Ironing out a new siderophore synthesis strategy

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Under iron-depleted conditions, bacteria produce siderophores that bind iron and are then actively taken up by the cell. New structural and biochemical insights are reported for the synthetic pathway of achromobactin, a siderophore from the plant pathogen Pectobacterium chrysanthemi.

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Figure 1: The reaction catalyzed by the NIS synthetase AcsD, from the achromobactin synthetic cluster.

References

  1. Miethke, M. & Marahiel, M.A. Microbiol. Mol. Biol. Rev. 71, 413–451 (2007).

    Article  CAS  Google Scholar 

  2. Challis, G.L. ChemBioChem 6, 601–611 (2005).

    Article  CAS  Google Scholar 

  3. Schmelz, S. et al. Nat. Chem. Biol. 5, 174–182 (2009).

    Article  CAS  Google Scholar 

  4. Kadi, N., Oves-Costales, D., Barona-Gomez, F. & Challis, G.L. Nat. Chem. Biol. 3, 652–656 (2007).

    Article  CAS  Google Scholar 

  5. Franza, T., Mahé, B. & Expert, D. Mol. Microbiol. 55, 261–275 (2005).

    Article  CAS  Google Scholar 

  6. Reger, A.S., Wu, R., Dunaway-Mariano, D. & Gulick, A.M. Biochemistry 47, 8016–8025 (2008).

    Article  CAS  Google Scholar 

  7. Wu, R. et al. Biochemistry 47, 8026–8039 (2008).

    Article  CAS  Google Scholar 

  8. Cisar, J.S. & Tan, D.S. Chem. Soc. Rev. 37, 1320–1329 (2008).

    Article  CAS  Google Scholar 

  9. Cendrowski, S., MacArthur, W. & Hanna, P. Mol. Microbiol. 51, 407–417 (2004).

    Article  CAS  Google Scholar 

  10. Lautru, S., Deeth, R.J., Bailey, L.M. & Challis, G.L. Nat. Chem. Biol. 1, 265–269 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Andrew M. Gulick is at the Hauptman-Woodward Medical Research Institute and Department of Structural Biology, University at Buffalo, 700 Ellicott Street, Buffalo, New York 14203, USA. gulick@hwi.buffalo.edu,

    Andrew M Gulick

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  1. Andrew M Gulick
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Gulick, A. Ironing out a new siderophore synthesis strategy. Nat Chem Biol 5, 143–144 (2009). https://doi.org/10.1038/nchembio0309-143

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