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Intracellular zinc irritates TRPA1

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Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.

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Figure 1: Activation of the irritant receptor TRPA1 on sensory neurons may mediate zinc toxicity.

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Authors and Affiliations

  1. Tue G. Banke and Alan D. Wickenden are at Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, USA. awickend@its.jnj.com,

    Tue G Banke & Alan D Wickenden

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  1. Tue G Banke
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  2. Alan D Wickenden
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Competing interests

The authors are employees of Johnson & Johnson Pharmaceutical Research and Development, LLC, which has conducted research relating to TRPA1.

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Banke, T., Wickenden, A. Intracellular zinc irritates TRPA1. Nat Chem Biol 5, 141–142 (2009). https://doi.org/10.1038/nchembio0309-141

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  • DOI: https://doi.org/10.1038/nchembio0309-141

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