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Alkaloid biosynthesis takes root

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Engineered biosynthesis of modified natural products normally uses microbes as biochemical factories. Now, chemical biologists are taking advantage of the largely untapped biochemical potential of plants.

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Figure 1: Hairy roots of Madagascar periwinkle transformed with the V214M strictosidine synthase produce modified monoterpene indole alkaloid natural products.

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Authors and Affiliations

  1. Katherine S. Ryan and Bradley S. Moore are at the Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. bsmoore@ucsd.edu,

    Katherine S Ryan & Bradley S Moore

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  1. Katherine S Ryan
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  2. Bradley S Moore
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Ryan, K., Moore, B. Alkaloid biosynthesis takes root. Nat Chem Biol 5, 140–141 (2009). https://doi.org/10.1038/nchembio0309-140

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