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Membrane proteins take center stage in Frankfurt

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Biological membranes are dynamic frontiers whose molecules must delicately balance the needs for compartmentalization and communication, and the gap between the vital significance of transport and signaling through membranes and our poor understanding of the precise functionality of these processes is daunting. However, a recent conference highlighted promising progress in the field, particularly made possible by the increasing structural knowledge about membrane proteins.

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Figure 1: Proposed model of FHA transport across the outer membrane.
Figure 2: Typical cycle for ion-coupled secondary transport involving cotransport of a substrate with an ion.
Figure 3: SRP-mediated protein translocation across membranes.

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Acknowledgements

We thank J. Pietzsch for his support in transferring specialized, expert knowledge into a general scientific form. We are grateful to J. Uphoff for excellent administrative co-organization. The meeting was supported by the SFB 807 “Membrane Transport and Communication” (Deutsche Forschungsgemeinschaft).

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Authors and Affiliations

  1. Enrico Schleiff is at the Center for Membrane Proteomics, the Cluster of Excellence Frankfurt and the Institute of Molecular Biosciences, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany. schleiff@bio.uni-frankfurt.de,

    Enrico Schleiff

  2. Robert Tampé is at the Center for Membrane Proteomics, the Cluster of Excellence Frankfurt and the Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany. tampe@em.uni-frankfurt.de,

    Robert Tampé

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  1. Enrico Schleiff
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Schleiff, E., Tampé, R. Membrane proteins take center stage in Frankfurt. Nat Chem Biol 5, 135–139 (2009). https://doi.org/10.1038/nchembio0309-135

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