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Arresting malaria parasite egress from infected red blood cells

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The escape of mature malaria parasites from the confines of their host red blood cells is an essential yet poorly understood process. Recent studies now highlight a key role for parasite proteases that trigger the degradation of parasite and host membranes, leading to the egress of infectious parasite forms.

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Figure 1: Proteases mediate egress of malaria parasites from the host red blood cell.

Kim Caesar

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Lee, M., Fidock, D. Arresting malaria parasite egress from infected red blood cells. Nat Chem Biol 4, 161–162 (2008). https://doi.org/10.1038/nchembio0308-161

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