Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesis of adenosylcobalamin, is shown to be involved in delivery of the cofactor to MCM.
References
Banerjee, R. ACS Chem. Biol. 1, 149–159 (2006).
Padovani, D., Labunska, T., Palfey, B.A., Ballou, D.P. & Banerjee, R. Nat. Chem. Biol. 4, 194–196 (2008).
Drennan, C.L., Huang, S., Drummond, J.T., Matthews, R.G. & Ludwig, M.L. Science 266, 1669–1674 (1994).
Shibata, N. et al. Structure 7, 997–1008 (1999).
Padmakumar, R., Taoka, S., Padmakumar, R. & Banerjee, R. J. Am. Chem. Soc. 117, 7033–7034 (1995).
Brown, K.L., Hakimi, J.M. & Jacobsen, D.W. J. Am. Chem. Soc. 106, 7894–7899 (1984).
Yamanishi, M., Labunska, T. & Banerjee, R. J. Am. Chem. Soc. 127, 526–527 (2005).
Korotkova, N. & Lidstrom, M.E. J. Biol. Chem. 279, 13652–13658 (2004).
Padovani, D. & Banerjee, R. Biochemistry 45, 9300–9306 (2006).
Hubbard, P.A. et al. J. Biol. Chem. 282, 31308–31316 (2007).
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Bandarian, V. Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase. Nat Chem Biol 4, 158–159 (2008). https://doi.org/10.1038/nchembio0308-158
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DOI: https://doi.org/10.1038/nchembio0308-158
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