Chemical and genetic approaches are extensively used to probe living systems at the subcellular level and to advance therapeutic target discovery. The 2006 American Society for Cell Biology meeting highlighted the growing importance of chemical biology approaches in cell biology research.
References
Mayer, T.U. et al. Science 286, 971–974 (1999).
Peters, U., Cherian, J., Kim, J.H., Kwok, B.H. & Kapoor, T.M. Nat. Chem. Biol. 2, 618–626 (2006).
De Toledo, M. et al. FEBS Lett. 480, 287–292 (2000).
Blangy, A. et al. Biol. Cell 98, 511–522 (2006).
Blangy, A. et al. J. Cell Sci. 113, 729–739 (2000).
Li, L. et al. Science 305, 1471–1474 (2004).
Knight, Z.A. et al. Cell 125, 733–747 (2006).
Fan, Q.W. et al. Cancer Cell 9, 341–349 (2006).
Toth, B. et al. J. Biol. Chem. 281, 36369–36377 (2006).
Kaehr, B. et al. Anal. Chem. 78, 3198–3202 (2006).
Kaehr, B., Allen, R., Javier, D.J., Currie, J. & Shear, J.B. Proc. Natl. Acad. Sci. USA 101, 16104–16108 (2004).
Kaehr, B. & Shear, J.B. J. Am. Chem. Soc. (in the press).
Griffin, B.A., Adams, S.R. & Tsien, R.Y. Science 281, 269–272 (1998).
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Hannoush, R. Probing cellular systems with chemistry. Nat Chem Biol 3, 131–134 (2007). https://doi.org/10.1038/nchembio0307-131
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DOI: https://doi.org/10.1038/nchembio0307-131
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