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Fluorescent timers shine a light on protein trafficking

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Monomeric fluorescent proteins that change their emission characteristics as they mature have been successfully used to study the spatial and temporal dynamics of lysosome-associated membrane protein type 2A. This methodology provides a new means of studying cellular events in a dynamic mode.

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Figure 1: Suggested mechanism of formation of the chromophore in the fluorescent timer proteins of Subach et al.3.

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Authors and Affiliations

  1. Emre Dikici and Sylvia Daunert are in the Department of Chemistry, Rose Street, University of Kentucky, Lexington, Kentucky 40506-0055, USA. daunert@uky.edu,

    Emre Dikici & Sylvia Daunert

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  1. Emre Dikici
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  2. Sylvia Daunert
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Dikici, E., Daunert, S. Fluorescent timers shine a light on protein trafficking. Nat Chem Biol 5, 70–71 (2009). https://doi.org/10.1038/nchembio0209-70

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