The MRN protein megacomplex mediates repair of double-stranded DNA breaks (DSBs) by tethering together broken ends of chromosomes and signaling a cascade of events required for DNA repair. The first small-molecule inhibitor that disrupts MRN function provides a valuable new tool for functional studies of DSB repair in cells.
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13 February 2009
In the version of this article initially published, the chemical structure of mirin in Figure 1b was incorrect. The error has been corrected in the HTML and PDF versions of the article.
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Stivers, J. Small molecule versus DNA repair nanomachine. Nat Chem Biol 4, 86–88 (2008). https://doi.org/10.1038/nchembio0208-86
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DOI: https://doi.org/10.1038/nchembio0208-86
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Erratum: Corrigendum: Small molecule versus DNA repair nanomachine
Nature Chemical Biology (2009)