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The proteasome makes sense of mixed signals

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Protein ubiquitination is an important degradative signal, yet not all ubiquitinated proteins are degraded. Recent results reveal insights into the proteasome's strategy for integrating biophysical signals when choosing substrates for degradation.

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Figure 1: Candidate substrates are localized to the proteasome through conjugated ubiquitin domains, and the presence of a USR is also important to initiate proteolytic degradation.

Kim Caesar

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Authors and Affiliations

  1. Thomas J. Wandless is in the Department of Chemical and Systems Biology, Stanford University, Clark Center, W350A, 318 Campus Drive, Stanford, California 94305-5441, USA. wandless@stanford.edu,

    Thomas J Wandless

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  1. Thomas J Wandless
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Wandless, T. The proteasome makes sense of mixed signals. Nat Chem Biol 5, 3–4 (2009). https://doi.org/10.1038/nchembio0109-3

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