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Drugs in action

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How do drugs work? What molecular changes do they cause in cells and in organisms? Is there a paradigm shift in the way we can predict and appreciate the impact of small molecules on biological systems in the 21st century? These were some of the questions addressed at a meeting in Vienna in August 2007.

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Figure 1: Small-molecule structures.
Figure 2: Cartoon of the interaction network of tyrosine kinase inhibitors imatinib, dasatinib and nilotinib with their respective protein targets.

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Acknowledgements

The meeting was sponsored by the European Molecular Biology Organization, ACS Chemical Biology, the Austrian Academy of Sciences, Boehringer Ingelheim, CeMM, GEN-AU, Nature Chemical Biology, Novartis, Roche, Thermo Fisher Scientific and Waters.

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Author notes

  1. Giulio Superti-Furga is at the Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 19, 1090 Vienna, Austria. gsuperti@cemm.oeaw.ac.at

Authors and Affiliations

  1. Ulrike S. Eggert is in the Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA. ulrike_eggert@dfci.harvard.edu,

    Ulrike S Eggert & Giulio Superti-Furga

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  1. Ulrike S Eggert
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  2. Giulio Superti-Furga
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Eggert, U., Superti-Furga, G. Drugs in action. Nat Chem Biol 4, 7–11 (2008). https://doi.org/10.1038/nchembio0108-7

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