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SAR by HCS

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The combination of high-content small-molecule screening information with computational tools offers the opportunity to obtain structure-activity relationships from complex cell-based data.

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Figure 1: Elucidating SAR information from cellular phenotypes.

Ann Thomson

References

  1. Lang, P., Yeow, K., Nichols, A. & Scheer, A. Nat. Rev. Drug Discov. 5, 343–356 (2006).

    Article  CAS  Google Scholar 

  2. Young, D.W. et al. Nat. Chem. Biol. 4, 59–68 (2008).

    Article  CAS  Google Scholar 

  3. Rausch, O. Curr. Opin. Chem. Biol. 10, 316–320 (2006).

    Article  CAS  Google Scholar 

  4. Spearman, C. Am. J. Psychol. 15, 201–293 (1904).

    Article  Google Scholar 

  5. Irish, J.M. et al. Cell 118, 217–228 (2004).

    Article  CAS  Google Scholar 

  6. Sachs, K. Science 308, 523–529 (2005).

    Article  CAS  Google Scholar 

  7. Butcher, E.C. Nat. Rev. Drug Discov. 4, 461–472 (2005).

    Article  CAS  Google Scholar 

  8. Giuliano, K.A., Johnston, P.A., Gough, A. & Taylor, D.L. Methods Enzymol. 414, 601–619 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Paul Lang is the head of the Department of Assay Development and Biomolecular Pharmacology, Merck Serono Geneva Research Center, 9 chemin des mines, 1211 Geneva, Switzerland. paul.lang@merckserono.net,

    Paul Lang

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  1. Paul Lang
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Lang, P. SAR by HCS. Nat Chem Biol 4, 18–19 (2008). https://doi.org/10.1038/nchembio0108-18

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  • DOI: https://doi.org/10.1038/nchembio0108-18

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