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RNA learns from antisense

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RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.

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Figure 1: Mechanisms for antisense oligonucleotides and siRNA.

Rebecca Henretta

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Acknowledgements

The author has been a consultant for Isis Pharmaceuticals. The author acknowledges support from the US National Institutes of Health (NIGMS 60642 and 73042) and the Robert A. Welch Foundation (I-1244).

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Authors and Affiliations

  1. the Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, 75390-9041, Texas, USA

    David R Corey

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  1. David R Corey
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Corey, D. RNA learns from antisense. Nat Chem Biol 3, 8–11 (2007). https://doi.org/10.1038/nchembio0107-8

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