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Chemical expansion of cofactor activity

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Methylation is a key regulatory event in several biological processes. The enzymatic transfer by methyltransferases of extended carbon chain analogs of S-adenosylmethionine to DNA opens up new avenues for investigating biological methylation.

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Figure 1: Selected cofactor analogs of interest in biological chemistry.

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Mercer, A., Burkart, M. Chemical expansion of cofactor activity. Nat Chem Biol 2, 8–10 (2006). https://doi.org/10.1038/nchembio0106-8

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