Ion channels have essential roles in the nervous system. An engineered ligand-gated channel with a photoactivated switch will be useful for addressing several issues in neuronal signaling.
References
Volgraf, M. et al. Nat. Chem. Biol. 2, 47–52 (2006).
Kramer, R.H., Chambers, J.J. & Trauner, D. Nat. Chem. Biol. 1, 360–365 (2005).
Banghart, M., Borges, K., Isacoff, E., Trauner, D. & Kramer, R.H. Nat. Neurosci. 7, 1381–1386 (2004).
Loudwig, S. & Bayley, H. in Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules (eds. Goeldner, M. & Givens, R.) (Wiley-VCH Verlag, Weinheim, Germany, 2005).
Chang, C.-Y., Niblack, B., Walker, B. & Bayley, H. Chem. Biol. 2, 391–400 (1995).
Koçer, A., Walko, M., Meijberg, W. & Feringa, B.L. Science 309, 755–758 (2005).
Lester, H.A. et al. J. Gen. Physiol. 75, 207–232 (1980).
Ghosh, M. et al. Science 304, 743–746 (2004).
Miller, J.C., Silverman, S.K., England, P.M., Dougherty, D.A. & Lester, H.A. Neuron 20, 619–624 (1998).
Tour, O., Meijer, R.M., Zacharias, D.A., Adams, S.R. & Tsien, R.Y. Nat. Biotechnol. 21, 1505–1508 (2003).
Astier, Y., Bayley, H. & Howorka, S. Curr. Opin. Chem. Biol. 9, 576–584 (2005).
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Bayley, H. Ion channels get flashy. Nat Chem Biol 2, 11–13 (2006). https://doi.org/10.1038/nchembio0106-11
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DOI: https://doi.org/10.1038/nchembio0106-11
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