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Alternative DNA structures

G4 DNA in cells: itae missa est?

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Application of a synthetic DNA G-quadruplex ligand as a genome-wide probe has provided evidence for G-quadruplex DNA clusters in human cells.

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Figure 1: Quadruplex ligands act at specific genomic clusters.

References

  1. Cahoon, L.A. & Seifert, H.S. Science 325, 764–767 (2009).

    Article  CAS  Google Scholar 

  2. Kruisselbrink, E. et al. Curr. Biol. 18, 900–905 (2008).

    Article  CAS  Google Scholar 

  3. Ribeyre, C. et al. PLoS Genet. 5, e1000475 (2009).

    Article  Google Scholar 

  4. Schaffitzel, C. et al. Proc. Natl. Acad. Sci. USA 98, 8572–8577 (2001).

    Article  CAS  Google Scholar 

  5. Rodriguez, R. et al. Nat. Chem. Biol. 8, 301–310 (2012).

    Article  CAS  Google Scholar 

  6. Mergny, J.L. et al. Science 256, 1681–1684 (1992).

    Article  CAS  Google Scholar 

  7. Sun, D. et al. J. Med. Chem. 40, 2113–2116 (1997).

    Article  CAS  Google Scholar 

  8. Rodriguez, R. et al. J. Am. Chem. Soc. 130, 15758–15759 (2008).

    Article  CAS  Google Scholar 

  9. Granotier, C. et al. Nucleic Acids Res. 33, 4182–4190 (2005).

    Article  CAS  Google Scholar 

  10. Piazza, A. et al. Nucleic Acids Res. 38, 4337–4348 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Jean-Louis Mergny is at the Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale, Institut Européen de Chimie-Biologie, Pessac, France.,

    Jean-Louis Mergny

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  1. Jean-Louis Mergny
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Correspondence to Jean-Louis Mergny.

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Mergny, JL. G4 DNA in cells: itae missa est?. Nat Chem Biol 8, 225–226 (2012). https://doi.org/10.1038/nchembio.793

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