Skip to main content
SpringerLink
Log in

Nuclear replication

Hidden iron-sulfur clusters

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The multisubunit DNA polymerases of eukaryotes have iron-sulfur centers that are crucial for polymerase assembly and therefore the integrity of the nuclear genome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Role of mitochondria and Fe-S clusters in nuclear DNA replication.

References

  1. Netz, D.J.A. et al. Nat. Chem. Biol. 8, 125–132 (2012).

    Article  CAS  Google Scholar 

  2. Klinge, S., Núñez-Ramírez, R., llorca, O & Pellegrini, L. EMBO J. 28, 1978–1987 (2009).

    Article  CAS  Google Scholar 

  3. Chanet, R. & Heude, M. Curr. Genet. 43, 337–350 (2003).

    Article  CAS  Google Scholar 

  4. Veatch, J.R., McMurray, M.A., Nelson, Z.W. & Gottschling, D.D. Cell 137, 1247–1258 (2005).

    Article  Google Scholar 

  5. Werner, M., Thuriaux, P. & Soutourina, J. Curr. Opin. Struct. Biol. 19, 740–745 (2009).

    Article  CAS  Google Scholar 

  6. Johansson, E. & MacNeill, S.A. Trends Biochem. Sci. 35, 339–347 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scott Bailey is in the Department of Biochemistry and Molecular Biology, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.,

    Scott Bailey

Authors
  1. Scott Bailey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Scott Bailey.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bailey, S. Hidden iron-sulfur clusters. Nat Chem Biol 8, 24–25 (2012). https://doi.org/10.1038/nchembio.737

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.737

  • Springer Nature America, Inc.

Search

Navigation