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Signaling pathways

Purinosomes under GPCR control

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Cell membrane–bound G protein–coupled receptors are traditionally thought to stimulate cell proliferation by addressing the nuclear replication machinery, but we now learn that they also activate cytosolic nucleotide factories, the purinosomes.

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Figure 1: From GPCR activation to mitosis.

Katie Vicari

References

  1. Rosenbaum, D.M., Rasmussen, S.G. & Kobilka, B.K. Nature 459, 356–363 (2009).

    Article  CAS  Google Scholar 

  2. Oldham, W.M. & Hamm, H.E. Nat. Rev. Mol. Cell Biol. 9, 60–71 (2008).

    Article  CAS  Google Scholar 

  3. Reiter, E., Ahn, S., Shukla, A.K. & Lefkowitz, R.J. Annu. Rev. Pharmacol. Toxicol. published online, 10.1146/annurev.pharmtox.010909.105800 (19 September 2011).

  4. Verrier, F. et al. Nat. Chem. Biol. 7, 909–915 (2011).

    Article  CAS  Google Scholar 

  5. An, S., Kumar, R., Sheets, E.D. & Benkovic, S.J. Science 320, 103–106 (2008).

    Article  CAS  Google Scholar 

  6. An, S., Kyoung, M., Allen, J.J., Shokat, K.M. & Benkovic, S.J. J. Biol. Chem. 285, 11093–11099 (2010).

    Article  CAS  Google Scholar 

  7. Schröder, R. et al. Nat. Biotechnol. 28, 943–949 (2010).

    Article  Google Scholar 

  8. Dorsam, R.T. & Gutkind, J.S. Nat. Rev. Cancer 7, 79–94 (2007).

    Article  CAS  Google Scholar 

  9. Lappano, R. & Maggiolini, M. Nat. Rev. Drug Discov. 10, 47–60 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. and the Pharmacology and Toxicology Section of the Department of Pharmacy, Evi Kostenis and Klaus Mohr are in the Molecular, Cellular and Pharmacobiology Section, University of Bonn, Germany.,

    Klaus Mohr & Evi Kostenis

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  1. Klaus Mohr
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  2. Evi Kostenis
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Correspondence to Klaus Mohr.

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A dynamic mass redistribution device has been provided to E.K. by Corning Inc.

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Mohr, K., Kostenis, E. Purinosomes under GPCR control. Nat Chem Biol 7, 860–861 (2011). https://doi.org/10.1038/nchembio.716

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