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Membrane trafficking

Arls squeeze the fat out

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Proteins binding to lipid moieties of GTPases can extract the GTPases from membranes. An innovative study shows that Arl2 and Arl3 act as dissociating factors that allosterically squeeze the lipid moiety of a GTPase from the grip of a lipid-binding protein, thereby facilitating reincorporation of the GTPase into membranes.

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Figure 1: Possible mechanisms for regulating the function of lipidated GTPase-binding proteins.

Katie Vicari

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  1. Roger L. Williams is in the Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.,

    Roger L Williams

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  1. Roger L Williams
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Correspondence to Roger L Williams.

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Williams, R. Arls squeeze the fat out. Nat Chem Biol 7, 863–864 (2011). https://doi.org/10.1038/nchembio.713

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