Monitoring oxygen (O2) levels is essential to optimizing aerobic metabolism and ensuring proper biological processes in most eukaryotes. The spice chemosensor TRPA1 is a previously unidentified O2 sensor in the mammalian sensory nervous system that warns against hyperoxia and hypoxia.
Change history
23 September 2011
In the version of this article initially published, on p.661, column 3, mustard oil was mistakenly grouped with cinnamaldehyde as an α,β-unsaturated carbonyl. The sentence should have read "...whereas α,β-unsaturated carbonyls such as cinnamaldehyde and the structurally unrelated mustard oil activate TRPA1 through the formation of Michael adducts..." The error has been corrected in the HTML and PDF versions of the article.
References
Takahashi, N. et al. Nat. Chem. Biol. 7, 701–711 (2011).
Baraldi, P.G., Preti, D., Materazzi, S. & Geppetti, P. J. Med. Chem. 53, 5085–5107 (2010).
Bautista, D.M. et al. Proc. Natl. Acad. Sci. USA 102, 12248–12252 (2005).
Story, G.M. et al. Cell 112, 819–829 (2003).
Fraisl, P., Aragones, J. & Carmeliet, P. Nat. Rev. Drug Discov. 8, 139–152 (2009).
Schuh-Hofer, S., Siekmann, W., Offenhauser, N., Reuter, U. & Arnold, G. Headache 46, 1545–1551 (2006).
Tzabazis, A.Z. et al. Life Sci. 87, 36–41 (2010).
Jordt, S.E. et al. Nature 427, 260–265 (2004).
Zygmunt, P.M., Andersson, D.A. & Högestätt, E.D. J. Neurosci. 22, 4720–4727 (2002).
Dowling, P., Klinker, F., Amaya, F., Paulus, W. & Liebetanz, D. J. Nutr. 139, 2087–2092 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Zygmunt, P. A TR(i)P in the air. Nat Chem Biol 7, 661–663 (2011). https://doi.org/10.1038/nchembio.669
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.669
- Springer Nature America, Inc.
This article is cited by
-
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity
Scientific Reports (2016)
-
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
Scientific Reports (2013)
-
Erratum: Corrigendum: A TR(i)P in the air
Nature Chemical Biology (2011)