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GPCRs

Caught in a spectroscopic trap

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Homo- and heterodimerization of G protein–coupled receptors (GPCRs) have been described for numerous receptors, but their functional role has remained elusive. With a new spectroscopic assay based on protein fragment complementation, GPCR heterodimerization was demonstrated to contribute to a phenomenon called 'functional selectivity'.

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Figure 1: Selectivity of GPCR activation assays by BRET and CODA-RET.

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Authors and Affiliations

  1. Jacob Piehler is in the Biology Department at the University of Osnabrück in Osnabrück, Germany.,

    Jacob Piehler

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  1. Jacob Piehler
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Correspondence to Jacob Piehler.

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The author declares no competing financial interests.

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Piehler, J. Caught in a spectroscopic trap. Nat Chem Biol 7, 578–579 (2011). https://doi.org/10.1038/nchembio.641

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