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Chronicles of the GTPase switch

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The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle are now well established, the next challenge is to reach an integrated view of how these proteins use it to orchestrate signaling pathways.

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Figure 1: The basics of the GDP-GTP switch of small GTPases.
Figure 2: The multispecificity of small GTPases.
Figure 3: The GTPase multiplexer model.

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Acknowledgements

This work was supported by the Centre National de la Recherche Scientifique, the Association pour la Recherche contre le Cancer and the Agence Nationale de la Recherche.

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Authors and Affiliations

  1. Jacqueline Cherfils and Mahel Zeghouf are in Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Centre de Recherche de Gif, Gif-sur-Yvette, France.,

    Jacqueline Cherfils & Mahel Zeghouf

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  1. Jacqueline Cherfils
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  2. Mahel Zeghouf
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Correspondence to Jacqueline Cherfils.

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Cherfils, J., Zeghouf, M. Chronicles of the GTPase switch. Nat Chem Biol 7, 493–495 (2011). https://doi.org/10.1038/nchembio.608

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