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Visualizing a neuronal handshake

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A new method to monitor interactions between cell surface proteins reveals that interaction of the neuronal cell surface adhesion proteins neurexin and neuroligin is increased at synapses during a stimulus or developmental activity. This increased activity-dependent surface density of neurexin–neuroligin complexes is subsequently required for maturation of synapses.

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Figure 1: Two methods for visualizing intercellular contact through heterophilic adhesion molecules.

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Authors and Affiliations

  1. Atsushi Miyawaki is in the Laboratory for Cell Function and Dynamics, Brain Science Institute, RIKEN, Wako City, Saitama, Japan, and the Life Function and Dynamics Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Wako City, Saitama, Japan.,

    Atsushi Miyawaki

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  1. Atsushi Miyawaki
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Correspondence to Atsushi Miyawaki.

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The author declares no competing financial interests.

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Miyawaki, A. Visualizing a neuronal handshake. Nat Chem Biol 6, 885–886 (2010). https://doi.org/10.1038/nchembio.486

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