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Grand Challenge Commentary: RNA epigenetics?

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Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of RNA. Understanding these RNA modification pathways and their functions may allow researchers to identify new layers of gene regulation at the RNA level.

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Figure 1: Examples of RNA modification and demodification that may impact biological regulation.

References

  1. Grosjean, H. (Ed.) Topics in Current Genetics Vol. 12 (Springer, Berlin, 2005).

    Google Scholar 

  2. Anderson, J. et al. Genes Dev. 12, 3650–3662 (1998).

    Article  CAS  Google Scholar 

  3. Saikia, M. et al. RNA 16, 1317–1327 (2010).

    Article  CAS  Google Scholar 

  4. Goll, M.G. et al. Science 311, 395–398 (2006).

    Article  CAS  Google Scholar 

  5. Schaefer, M. & Lyko, F. Chromosoma 119, 35–40 (2010).

    Article  CAS  Google Scholar 

  6. Yan, F. et al. J. Am. Chem. Soc. 132, 3953–3964 (2010).

    Article  CAS  Google Scholar 

  7. Toh, S.M. et al. Mol. Microbiol. 64, 1506–1514 (2007).

    Article  CAS  Google Scholar 

  8. Yi, C., Yang, C.G. & He, C. Acc. Chem. Res. 42, 519–529 (2009).

    Article  CAS  Google Scholar 

  9. Trewick, S.C. et al. Nature 419, 174–178 (2002).

    Article  CAS  Google Scholar 

  10. Falnes, P.Ø., Johansen, R.F. & Seeberg, E. Nature 419, 178–182 (2002).

    Article  CAS  Google Scholar 

  11. Fu, Y. et al. Angew. Chem. Int. Ed. published online, doi:10.1002/anie.201001242 (25 June 2010).

  12. Shimada, K. et al. Cancer Res. 69, 3157–3164 (2009).

    Article  CAS  Google Scholar 

  13. Aas, P.A. et al. Nature 421, 859–863 (2003).

    Article  CAS  Google Scholar 

  14. Shimada, K. et al. Cancer Sci. 99, 39–45 (2008).

    CAS  PubMed  Google Scholar 

  15. Frayling, T.M. et al. Science 316, 889–894 (2007).

    Article  CAS  Google Scholar 

  16. Dina, C. et al. Nat. Genet. 39, 724–726 (2007).

    Article  CAS  Google Scholar 

  17. Scott, L.J. et al. Science 316, 1341–1345 (2007).

    Article  CAS  Google Scholar 

  18. Gerken, T. et al. Science 318, 1469–1472 (2007).

    Article  CAS  Google Scholar 

  19. Webby, C.J. et al. Science 325, 90–93 (2009).

    Article  CAS  Google Scholar 

  20. Hong, X. et al. Proc. Natl. Acad. Sci. USA 107, 14568–14572 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Chuan He is in the Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA.,

    Chuan He

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  1. Chuan He
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Correspondence to Chuan He.

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He, C. Grand Challenge Commentary: RNA epigenetics?. Nat Chem Biol 6, 863–865 (2010). https://doi.org/10.1038/nchembio.482

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