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DNA replication

Changing faces, trading places

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Mutually exclusive post-translational modifications of flap endonuclease 1 (FEN1) regulate its binding to proliferating cell nuclear antigen (PCNA) and govern its various modes of DNA interaction during DNA replication and repair.

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Figure 1: Possible roles for antagonistic methylation-phosphorylation in FEN1 function.

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Authors and Affiliations

  1. Judith L. Campbell is in the Divisions of Biology and Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.,

    Judith L Campbell

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  1. Judith L Campbell
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Correspondence to Judith L Campbell.

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The author declares no competing financial interests.

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Campbell, J. Changing faces, trading places. Nat Chem Biol 6, 701–702 (2010). https://doi.org/10.1038/nchembio.444

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