Skip to main content
SpringerLink
Log in

Drug discovery

Engineering drug combinations

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The level of an individual protein in cells treated with combinations of drugs is best explained by simple linear superposition of the protein levels in response to single drugs. This finding may facilitate rational design of higher order drug combinations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The uses of drug combination therapies and how future therapies may be predicted.

References

  1. Bates, S. Drug Discov. Today 15, 115–120 (2010).

    Article  Google Scholar 

  2. Jia, J. et al. Nat. Rev. Drug Discov. 8, 111–128 (2009).

    Article  CAS  Google Scholar 

  3. Araujo, R.P., Liotta, L.A. & Petricoin, E.F. Nat. Rev. Drug Discov. 6, 871–880 (2007).

    Article  CAS  Google Scholar 

  4. Palella, F.J. Jr. et al. N. Engl. J. Med. 338, 853–860 (1998).

    Article  Google Scholar 

  5. Armitage, J.O. N. Engl. J. Med. 328, 1023–1030 (1993).

    Article  CAS  Google Scholar 

  6. Kroiss, J. et al. Nat. Chem. Biol. 6, 261–263 (2010).

    Article  CAS  Google Scholar 

  7. Geva-Zatorsky, N. et al. Cell 140, 643–651 (2010).

    Article  CAS  Google Scholar 

  8. Sigal, A. et al. Nat. Methods 3, 525–531 (2006).

    Article  CAS  Google Scholar 

  9. Cohen, A.A. et al. Science 322, 1511–1516 (2008).

    Article  CAS  Google Scholar 

  10. Lehar, J. et al. Mol. Syst. Biol. 3, 80 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scott J. Dixon is in the Department of Biological Sciences, New York, New York, USA,

    Scott J Dixon

  2. Brent R. Stockwell is at the Howard Hughes Medical Institute and in the Departments of Biological Sciences and Chemistry, Columbia University, New York, New York, USA.,

    Brent R Stockwell

Authors
  1. Scott J Dixon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brent R Stockwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brent R Stockwell.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dixon, S., Stockwell, B. Engineering drug combinations. Nat Chem Biol 6, 318–319 (2010). https://doi.org/10.1038/nchembio.353

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.353

  • Springer Nature America, Inc.

Search

Navigation