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Flies feel your pain

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Evolutionary conservation of TRPA1 underlies sensation of reactive noxious chemicals from flies to humans.

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Figure 1: The conserved sensitivity of TRPA1 receptors to reactive electrophiles allows both flies and humans to detect potentially harmful chemicals.

KATIE VICARI

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Authors and Affiliations

  1. Lindsey J. Macpherson is in the Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.,

    Lindsey J Macpherson

  2. and the Department of Cell Biology, Ardem Patapoutian is in the Genomics Institute of the Novartis Research Foundation, San Diego, California, USA, The Scripps Research Institute, La Jolla, California, USA.,

    Ardem Patapoutian

Authors
  1. Lindsey J Macpherson
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  2. Ardem Patapoutian
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Correspondence to Ardem Patapoutian.

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The authors declare no competing financial interests.

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Macpherson, L., Patapoutian, A. Flies feel your pain. Nat Chem Biol 6, 252–253 (2010). https://doi.org/10.1038/nchembio.339

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