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Kinase inhibitors

Narrowing down the real targets

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Many kinase inhibitors for cancer therapy are rather nonselective, and their cellular mechanisms of action are incompletely understood. A nested chemical proteomics and chemical genetics strategy reveals which cellular targets of the clinical kinase inhibitor dasatinib functionally relate to its anti-oncogenic activity.

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Figure 1: Nested chemical proteomics and genetics strategy for kinase inhibitor analysis.

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Authors and Affiliations

  1. Department of Molecular Biology, Henrik Daub is in the Project Group Cell Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.,

    Henrik Daub

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  1. Henrik Daub
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Correspondence to Henrik Daub.

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Competing interests

H.D. is a shareholder of and has a consultancy agreement with Kinaxo Biotechnologies GmbH.

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Daub, H. Narrowing down the real targets. Nat Chem Biol 6, 249–250 (2010). https://doi.org/10.1038/nchembio.336

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  • DOI: https://doi.org/10.1038/nchembio.336

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