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Synthetic chemistry

An upfront investment

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A Corrigendum to this article was published on 01 April 2010

This article has been updated

Organic synthesis plays a leading role in the discovery of small molecules for the exploration of biological systems. Therefore, the development of efficient strategies for the preparation of these molecules is a necessary aspect of the small-molecule approach to chemical biology.

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Figure 1: Synthesis of chroman and isochroman scaffolds.

Change history

  • 18 March 2010

    In the version of this article initially published, the palladium catalyst was incorrectly drawn as PdPh4. The molecular formula is actually Pd(PPh3)4. The error has been corrected in the HTML and PDF versions of the article.

References

  1. Schreiber, S.L. Chemical Biology: From Small Molecules to Systems Biology and Drug Design (Wiley-VCH, 2008).

    Google Scholar 

  2. Leibeling, M. et al. Nat. Chem. Biol. 6, 199–201 (2010).

    Article  CAS  Google Scholar 

  3. Stanton, B.Z. et al. Nat. Chem. Biol. 5, 154–156 (2009).

    Article  CAS  Google Scholar 

  4. Bender C.F. et al. J. Am. Chem. Soc. 131, 11351–11352 (2009)

    Article  Google Scholar 

  5. Wong, C.-H. Carbohydrate-based Drug Discovery (Wiley-VCH, 2003).

    Book  Google Scholar 

  6. Hegedus, L. Transition Metals in the Synthesis of Complex Organic Molecules (University Science Books, 1999).

    Google Scholar 

  7. Poli, G. et al. Tetrahedron 56, 5959–5989 (2000).

    Article  CAS  Google Scholar 

  8. Payne, D.J. et al. Nat. Rev. Drug Disc. 6, 29–40 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Damian W. Young is in the Chemical Biology Program at the Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.,

    Damian W Young

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  1. Damian W Young
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Correspondence to Damian W Young.

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The author declares no competing financial interests.

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Young, D. An upfront investment. Nat Chem Biol 6, 174–175 (2010). https://doi.org/10.1038/nchembio.325

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