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Genomic variations on a CoA biosynthetic theme

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A unique heterotrimeric assembly of individually inactive paralogs, two of which are also involved in regulating phosphatase activity, creates one of the key enzymes of coenzyme A biosynthesis in yeast, pointing to the possibility of a previously undescribed cross-talk between metabolic and signaling pathways.

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Figure 1: Coenzyme A assembly line with variations.

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Authors and Affiliations

  1. Andrei L. Osterman is at the Burnham Institute for Medical Research, La Jolla, California, USA, and the Fellowship for Interpretation of Genomes, Burr Ridge, Illinois, USA.,

    Andrei L Osterman

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  1. Andrei L Osterman
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Correspondence to Andrei L Osterman.

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Osterman, A. Genomic variations on a CoA biosynthetic theme. Nat Chem Biol 5, 871–872 (2009). https://doi.org/10.1038/nchembio.267

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