Vibrio cholerae produces cholera autoinducer-1 (CAI-1), a signaling molecule previously believed to be synthesized by the CqsA enzyme. Here it is shown that CqsA does not directly synthesize CAI-1; instead, it synthesizes amino-CAI-1, which is then converted into CAI-1 in a CqsA-independent manner.
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Sperandio, V. Deciphering bacterial language. Nat Chem Biol 5, 870–871 (2009). https://doi.org/10.1038/nchembio.263
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DOI: https://doi.org/10.1038/nchembio.263
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