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PKR and the ribosome compete for mRNA

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The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

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Figure 1: Model for regulating translation by IFN-γ mRNA.

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Authors and Affiliations

  1. Rebecca Toroney and Philip C. Bevilacqua are in the Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.,

    Rebecca Toroney & Philip C Bevilacqua

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  1. Rebecca Toroney
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  2. Philip C Bevilacqua
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Correspondence to Philip C Bevilacqua.

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Toroney, R., Bevilacqua, P. PKR and the ribosome compete for mRNA. Nat Chem Biol 5, 873–874 (2009). https://doi.org/10.1038/nchembio.262

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