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On the mechanism of iron sensing by IRP2: new players, new paradigms

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Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.

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Figure 1: Iron- and oxygen-mediated modification of proteins required for regulation of iron metabolism.

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Authors and Affiliations

  1. Diane McVey Ward and Jerry Kaplan are in the Department of Pathology, Naoko Takahashi-Makise, University of Utah School of Medicine, Salt Lake City, Utah, USA.,

    Naoko Takahashi-Makise, Diane McVey Ward & Jerry Kaplan

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  1. Naoko Takahashi-Makise
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  2. Diane McVey Ward
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  3. Jerry Kaplan
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Correspondence to Jerry Kaplan.

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Takahashi-Makise, N., Ward, D. & Kaplan, J. On the mechanism of iron sensing by IRP2: new players, new paradigms. Nat Chem Biol 5, 874–875 (2009). https://doi.org/10.1038/nchembio.261

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