Skip to main content
SpringerLink
Log in

Biosynthesis

SAM cycles up for colibactin

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: SAM is both an aminobutaryl donor and a precursor of cyclopropyl groups.

References

  1. Vizcaino, M.I. & Crawford, J.M. Nat. Chem. 7, 411–417 (2015).

    Article  CAS  Google Scholar 

  2. Zha, L. et al. Nat. Chem. Biol. 13, 1063–1065 (2017).

    Article  CAS  Google Scholar 

  3. Loenen, W.A. Biochem. Soc. Trans. 34, 330–333 (2006).

    Article  CAS  Google Scholar 

  4. Boller, T., Herner, R.C. & Kende, H. Planta 145, 293–303 (1979).

    Article  CAS  Google Scholar 

  5. Yu, Y.-B., Adams, D.O. & Yang, S.F. Arch. Biochem. Biophys. 198, 280–286 (1979).

    Article  CAS  Google Scholar 

  6. Hiratsuka, T., Suzuki, H., Minami, A. & Oikawa, H. Org. Biomol. Chem. 15, 1076–1079 (2017).

    Article  CAS  Google Scholar 

  7. Yuan, Y. & Barry, C.E., III . Proc. Natl. Acad. Sci. USA 93, 12828–12833 (1996).

    Article  CAS  Google Scholar 

  8. Trautman, E.P., Healy, A.R., Shine, E.E., Herzon, S.B. & Crawford, J.M. J. Am. Chem. Soc. 139, 4195–4201 (2017).

    Article  CAS  Google Scholar 

  9. Brachmann, A.O. et al. Chem. Commun. (Camb.) 51, 13138–13141 (2015).

    Article  CAS  Google Scholar 

  10. Vaillancourt, F.H., Yeh, E., Vosburg, D.A., O'Connor, S.E. & Walsh, C.T. Nature 436, 1191–1194 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA

    Steven G Van Lanen

Authors
  1. Steven G Van Lanen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Steven G Van Lanen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Van Lanen, S. SAM cycles up for colibactin. Nat Chem Biol 13, 1059–1061 (2017). https://doi.org/10.1038/nchembio.2479

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.2479

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation