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Extracellular vesicles

Taking metabolism on the road

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Extracellular vesicles (EVs) are a class of secreted membrane particles capable of transferring biological molecules between cells. Metabolomics measurements indicate that isolated EVs also have autonomous metabolic enzyme activities, including the unexpected identification of endogenous human asparaginase activity.

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Figure 1: Mechanisms by which extracellular vesicles (EVs) can alter organismal metabolism.

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  1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Lucas B Sullivan

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  1. Lucas B Sullivan
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Correspondence to Lucas B Sullivan.

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Sullivan, L. Taking metabolism on the road. Nat Chem Biol 13, 924–925 (2017). https://doi.org/10.1038/nchembio.2455

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