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Peptidoglycan

Another brick in the wall

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Lipid II embodies the bricks used to build the essential bacterial cell wall component peptidoglycan. A facile new procedure for preparation of species-specific Lipid II in high yields can now be used to unlock the door to antibiotic discovery.

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Figure 1: Production of Lipid II and its use to assay penicillin-binding proteins (PBPs).

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

    Anthony J Clarke

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  1. Anthony J Clarke
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Correspondence to Anthony J Clarke.

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The author declares no competing financial interests.

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Clarke, A. Another brick in the wall. Nat Chem Biol 13, 695–696 (2017). https://doi.org/10.1038/nchembio.2419

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  • DOI: https://doi.org/10.1038/nchembio.2419

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