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Unraveling cell-to-cell signaling networks with chemical biology

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Cell-to-cell signaling networks, although poorly understood, guide tissue development, regulate tissue function and may become dysregulated in disease. Chemical biologists can develop the next generation of tools to untangle these complex and dynamic networks of interacting cells.

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Figure 1: Cell-to-cell signaling networks in epithelial tissues and the immune system.

MARINA CORRAL SPENCE/SPRINGER NATURE

Figure 2: Chemical biology tools to image, perturb and engineer intracellular and intercellular signaling networks.

MARINA CORRAL SPENCE/SPRINGER NATURE

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Author information

Authors and Affiliations

  1. Zev J. Gartner is at the Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.,

    Zev J Gartner

  2. Jennifer A. Prescher is at the Department of Chemistry, University of California, Irvine, Irvine, California, USA.,

    Jennifer A Prescher

  3. Luke D. Lavis is at the Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.,

    Luke D Lavis

Authors
  1. Zev J Gartner
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  2. Jennifer A Prescher
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  3. Luke D Lavis
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Corresponding authors

Correspondence to Zev J Gartner, Jennifer A Prescher or Luke D Lavis.

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Competing interests

Z.J.G. holds stock in a company that has licensed patents on DNA-Programmed Assembly of Cells from the University of California, San Francisco.

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Gartner, Z., Prescher, J. & Lavis, L. Unraveling cell-to-cell signaling networks with chemical biology. Nat Chem Biol 13, 564–568 (2017). https://doi.org/10.1038/nchembio.2391

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