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Spatial regulation of axonal cAMP

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In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.

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Figure 1: Removal of an AKAP-dependent negative feedback on cAMP during development allows for the production of cAMP responses, with higher efficacy in distal axon.

References

  1. Taylor, S.S., Ilouz, R., Zhang, P. & Kornev, A.P. Nat. Rev. Mol. Cell Biol. 13, 646–658 (2012).

    Article  CAS  Google Scholar 

  2. Conti, M., Mika, D. & Richter, W. J. Gen. Physiol. 143, 29–38 (2014).

    Article  CAS  Google Scholar 

  3. Gorshkov, K. et al. Nat. Chem. Biol. 13, 425–431 (2017).

    Article  CAS  Google Scholar 

  4. Shelly, M. et al. Science 327, 547–552 (2010).

    Article  CAS  Google Scholar 

  5. Nicol, X., Hong, K.P. & Spitzer, N.C. Proc. Natl. Acad. Sci. USA 108, 13776–13781 (2011).

    Article  CAS  Google Scholar 

  6. Gervasi, N. et al. J. Neurosci. 27, 2744–2750 (2007).

    Article  CAS  Google Scholar 

  7. Gervasi, N., Tchénio, P. & Preat, T. Neuron 65, 516–529 (2010).

    Article  CAS  Google Scholar 

  8. Castro, L.R. et al. J. Neurosci. 30, 6143–6151 (2010).

    Article  CAS  Google Scholar 

  9. Maiellaro, I., Lohse, M.J., Kittel, R.J. & Calebiro, D. Cell Rep. 17, 1238–1246 (2016).

    Article  CAS  Google Scholar 

  10. Averaimo, S. et al. Nat. Commun. 7, 12896 (2016).

    Article  CAS  Google Scholar 

  11. Dunn, T.A. & Feller, M.B. Dev. Neurobiol. 68, 835–844 (2008).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Liliana R Castro and Pierre Vincent are in the Institut de Biologie Paris–Seine, Paris, France and the Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.,

    Pierre Vincent & Liliana R Castro

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  1. Pierre Vincent
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  2. Liliana R Castro
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Correspondence to Pierre Vincent.

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The authors declare no competing financial interests.

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Vincent, P., Castro, L. Spatial regulation of axonal cAMP. Nat Chem Biol 13, 348–349 (2017). https://doi.org/10.1038/nchembio.2339

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