Intrinsically disordered proteins (IDPs) are subject to ubiquitin-independent degradation, a default and passive process. We describe here a model wherein a group of 'nanny' proteins function to protect newly synthesized IDPs from degradation by default, thereby insuring their maturation into important regulatory molecules.
This is a preview of subscription content, log in via an institution to check access.
References
Wright, P.E. & Dyson, H.J. J. Mol. Biol. 293, 321–331 (1999).
Ward, J.J., Sodhi, J.S., McGuffin, L.J., Buxton, B.F. & Jones, D.T. J. Mol. Biol. 337, 635–645 (2004).
Gsponer, J., Futschik, M.E., Teichmann, S.A. & Babu, M.M. Science 322, 1365–1368 (2008).
Chiti, F. & Dobson, C.M. Annu. Rev. Biochem. 75, 333–366 (2006).
Asher, G., Reuven, N. & Shaul, Y. Bioessays 28, 844–849 (2006).
Tsvetkov, P. et al. Proteins 70, 1357–1366 (2008).
Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).
Bloom, J. & Pagano, M. Cell Cycle 3, 138–140 (2004).
Tofaris, G.K., Layfield, R. & Spillantini, M.G. FEBS Lett. 509, 22–26 (2001).
Boyd, N.F. et al. Br. J. Cancer 89, 1672–1685 (2003).
Tsvetkov, P., Reuven, N. & Shaul, Y. Cell Death Differ. (in the press).
Koshland, D.E. Proc. Natl. Acad. Sci. USA 44, 98–104 (1958).
Oldfield, C.J. et al. Biochemistry 44, 12454–12470 (2005).
Tompa, P. & Fuxreiter, M. Trends Biochem. Sci. 33, 2–8 (2008).
Bell, S., Klein, C., Muller, L., Hansen, S. & Buchner, J. J. Mol. Biol. 322, 917–927 (2002).
Tsvetkov, P., Reuven, N., Prives, C. & Shaul, Y. J. Biol. Chem. 284, 26234–26242 (2009).
Ongkeko, W.M. et al. Curr. Biol. 9, 829–832 (1999).
Fink, A.L. Physiol. Rev. 79, 425–449 (1999).
Hegyi, H. & Tompa, P. PLoS Comput. Biol. 4, e1000017 (2008).
Krappmann, D., Wulczyn, F.G. & Scheidereit, C. EMBO J. 15, 6716–6726 (1996).
O'Dea, E.L., Kearns, J.D. & Hoffmann, A. Mol. Cell 30, 632–641 (2008).
Errami, A. et al. Mol. Cell. Biol. 16, 1519–1526 (1996).
Gu, Y. et al. Immunity 7, 653–665 (1997).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tsvetkov, P., Reuven, N. & Shaul, Y. The nanny model for IDPs. Nat Chem Biol 5, 778–781 (2009). https://doi.org/10.1038/nchembio.233
Issue Date:
DOI: https://doi.org/10.1038/nchembio.233
- Springer Nature America, Inc.
This article is cited by
-
Structural biases in disordered proteins are prevalent in the cell
Nature Structural & Molecular Biology (2024)
-
Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family
Nature Communications (2023)
-
Degron masking outlines degronons, co-degrading functional modules in the proteome
Communications Biology (2022)
-
PA28γ–20S proteasome is a proteolytic complex committed to degrade unfolded proteins
Cellular and Molecular Life Sciences (2022)
-
Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
Cell Communication and Signaling (2020)