Proteolytic maturation of an important transcriptional regulator is performed by a glycosyltransferase. The reaction involves glycosylation of a glutamate residue and conversion of the γ-glycosyl ester product into an N-acyl pyroglutamate, which undergoes spontaneous hydrolysis to effect peptide backbone fission.
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Goddard-Borger, E. Sugary shears. Nat Chem Biol 12, 892–893 (2016). https://doi.org/10.1038/nchembio.2216
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DOI: https://doi.org/10.1038/nchembio.2216
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